Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium
Identifieur interne : 00B345 ( Main/Exploration ); précédent : 00B344; suivant : 00B346Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium
Auteurs : Deborah Thompson [Royaume-Uni] ; Csilla I. Szabo [France] ; Jon Mangion [Royaume-Uni] ; Rogier A. Oldenburg [Pays-Bas] ; Fabrice Odefrey [France] ; Sheila Seal [Royaume-Uni] ; Rita Barfoot [Royaume-Uni] ; Karin Kroeze-Jansema [Pays-Bas] ; Dawn Teare [Royaume-Uni] ; Nazneen Rahman [Royaume-Uni] ; Hélène Renard [France] ; Graham Mann [Australie] ; John L. Hopper [Australie] ; Saundra S. Buys [États-Unis] ; Irene L. Andrulis [Canada] ; Ruby Senie [États-Unis] ; Mary B. Daly [États-Unis] ; Dee West [Royaume-Uni, États-Unis] ; Elaine A. Ostrander [États-Unis] ; Ken Offit [États-Unis] ; Tamar Peretz [Israël] ; Ana Osorio [Espagne] ; J. Benitez [Espagne] ; Katherine L. Nathanson [États-Unis] ; Olga M. Sinilnikova [France] ; Edith Olàh [Hongrie] ; Yves-Jean Bignon [France] ; Pablo Ruiz [Mexique] ; Michael D. Badzioch [France] ; Hans F. A. Vasen [Pays-Bas] ; Andrew P. Futreal [Royaume-Uni] ; Catherine M. Phelan [Canada] ; Steven A. Narod [Canada] ; Henry T. Lynch [États-Unis] ; Bruce A. J. Ponder [Royaume-Uni] ; Ros A. Eeles [Royaume-Uni] ; Hanne Meijers-Heijboer [Royaume-Uni] ; Dominique Stoppa-Lyonnet [France] ; Fergus J. Couch [Royaume-Uni] ; Diana M. Eccles [Pays-Bas] ; D. Gareth Evans ; Jenny Chang-Claude ; Gilbert Lenoir [France] ; Barbara L. Weber [États-Unis] ; Peter Devilee [Pays-Bas] ; Douglas F. Easton [Royaume-Uni] ; David E. Goldgar [France, Australie] ; Michael R. Stratton [Royaume-Uni]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2002.
Abstract
The known susceptibility genes for breast cancer, including BRCA1 and BRCA2, only account for a minority of the familial aggregation of the disease. A recent study of 77 multiple case breast cancer families from Scandinavia found evidence of linkage between the disease and polymorphic markers on chromosome 13q21. We have evaluated the contribution of this candidate “BRCA3” locus to breast cancer susceptibility in 128 high-risk breast cancer families of Western European ancestry with no identified BRCA1 or BRCA2 mutations. No evidence of linkage was found. The estimated proportion (α) of families linked to a susceptibility locus at D13S1308, the location estimated by Kainu
Url:
DOI: 10.1073/pnas.012584499
PubMed: 11792833
PubMed Central: 117390
Affiliations:
- Australie, Canada, Espagne, France, Hongrie, Israël, Mexique, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, Auvergne (région administrative), Auvergne-Rhône-Alpes, Californie, Communauté de Madrid, Hollande-Méridionale, Hongrie centrale, Nebraska, Pennsylvanie, Rhône-Alpes, Utah, Victoria (État), Washington (État), État de New York
- Budapest, Cambridge, Clermont-Ferrand, Leyde, Lyon, Madrid, Melbourne
- Université de Cambridge, Université de Melbourne
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000A25
- to stream Pmc, to step Curation: 000A02
- to stream Pmc, to step Checkpoint: 002D46
- to stream Ncbi, to step Merge: 000043
- to stream Ncbi, to step Curation: 000043
- to stream Ncbi, to step Checkpoint: 000043
- to stream Main, to step Merge: 00C134
- to stream Main, to step Curation: 00B345
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium</title><author><name sortKey="Thompson, Deborah" sort="Thompson, Deborah" uniqKey="Thompson D" first="Deborah" last="Thompson">Deborah Thompson</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Mangion, Jon" sort="Mangion, Jon" uniqKey="Mangion J" first="Jon" last="Mangion">Jon Mangion</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Oldenburg, Rogier A" sort="Oldenburg, Rogier A" uniqKey="Oldenburg R" first="Rogier A." last="Oldenburg">Rogier A. Oldenburg</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Seal, Sheila" sort="Seal, Sheila" uniqKey="Seal S" first="Sheila" last="Seal">Sheila Seal</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Barfoot, Rita" sort="Barfoot, Rita" uniqKey="Barfoot R" first="Rita" last="Barfoot">Rita Barfoot</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Kroeze Jansema, Karin" sort="Kroeze Jansema, Karin" uniqKey="Kroeze Jansema K" first="Karin" last="Kroeze-Jansema">Karin Kroeze-Jansema</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Teare, Dawn" sort="Teare, Dawn" uniqKey="Teare D" first="Dawn" last="Teare">Dawn Teare</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Renard, Helene" sort="Renard, Helene" uniqKey="Renard H" first="Hélène" last="Renard">Hélène Renard</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Mann, Graham" sort="Mann, Graham" uniqKey="Mann G" first="Graham" last="Mann">Graham Mann</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Westmead Institute for Cancer Research, University of Sydney at Westmead, Millennium Institute, Westmead NSW 2145, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Westmead Institute for Cancer Research, University of Sydney at Westmead, Millennium Institute, Westmead NSW 2145</wicri:regionArea><wicri:noRegion>Westmead NSW 2145</wicri:noRegion></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">Centre for Genetic Epidemiology, University of Melbourne, Melbourne 3002, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Genetic Epidemiology, University of Melbourne, Melbourne 3002</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Hematology–Oncology, University of Utah, Salt Lake City, UT 84132;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Department of Hematology–Oncology, University of Utah, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5;</nlm:aff><country>Canada</country><wicri:regionArea>Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Senie, Ruby" sort="Senie, Ruby" uniqKey="Senie R" first="Ruby" last="Senie">Ruby Senie</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Mailman School of Public Health, Columbia University, New York, NY 10032;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Mailman School of Public Health, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Fox Chase Cancer Center, Philadelphia, PA 19012;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Fox Chase Cancer Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="West, Dee" sort="West, Dee" uniqKey="West D" first="Dee" last="West">Dee West</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Northern California Cancer Center, Union City, CA 94587;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Northern California Cancer Center, Union City</wicri:cityArea></affiliation></author><author><name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Offit, Ken" sort="Offit, Ken" uniqKey="Offit K" first="Ken" last="Offit">Ken Offit</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Clinical Genetics Service, Department of Medicine, Memorial Sloan–Kettering Cancer Center, New York, NY 10021;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Clinical Genetics Service, Department of Medicine, Memorial Sloan–Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Peretz, Tamar" sort="Peretz, Tamar" uniqKey="Peretz T" first="Tamar" last="Peretz">Tamar Peretz</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Sharett Institute of Oncology, Hebrew University-Hadassah Medical Center, Jerusalem 91120, Israel;</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Sharett Institute of Oncology, Hebrew University-Hadassah Medical Center, Jerusalem 91120</wicri:regionArea><wicri:noRegion>Jerusalem 91120</wicri:noRegion></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Departmento de Genetica Humana, Centro Nacional Investigaciones Oncologicas, 28220 Madrid, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departmento de Genetica Humana, Centro Nacional Investigaciones Oncologicas, 28220 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J." last="Benitez">J. Benitez</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Departmento de Genetica Humana, Centro Nacional Investigaciones Oncologicas, 28220 Madrid, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departmento de Genetica Humana, Centro Nacional Investigaciones Oncologicas, 28220 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olàh">Edith Olàh</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Division of Molecular Biology, National Cancer Institute, H-1122, Budapest, Hungary;</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Division of Molecular Biology, National Cancer Institute, H-1122, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Bignon, Yves Jean" sort="Bignon, Yves Jean" uniqKey="Bignon Y" first="Yves-Jean" last="Bignon">Yves-Jean Bignon</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unité d'Oncogénétique and Unité INSERM CRI 9502 & EA 2145, Centre Jean-Perrin, 63011 Clermont-Ferrand, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité d'Oncogénétique and Unité INSERM CRI 9502 & EA 2145, Centre Jean-Perrin, 63011 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Ruiz, Pablo" sort="Ruiz, Pablo" uniqKey="Ruiz P" first="Pablo" last="Ruiz">Pablo Ruiz</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, 64460, Mexico;</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, 64460</wicri:regionArea><wicri:noRegion>64460</wicri:noRegion></affiliation></author><author><name sortKey="Badzioch, Michael D" sort="Badzioch, Michael D" uniqKey="Badzioch M" first="Michael D." last="Badzioch">Michael D. Badzioch</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Vasen, Hans F A" sort="Vasen, Hans F A" uniqKey="Vasen H" first="Hans F. A." last="Vasen">Hans F. A. Vasen</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Futreal, Andrew P" sort="Futreal, Andrew P" uniqKey="Futreal A" first="Andrew P." last="Futreal">Andrew P. Futreal</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Cancer Genome Project, Sanger Centre, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Sanger Centre, Wellcome Trust Genome Campus, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M." last="Phelan">Catherine M. Phelan</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Centre for Research in Women's Health, Women's College Hospital, Toronto, ON, Canada M5G 1N9;</nlm:aff><country>Canada</country><wicri:regionArea>Centre for Research in Women's Health, Women's College Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Narod, Steven A" sort="Narod, Steven A" uniqKey="Narod S" first="Steven A." last="Narod">Steven A. Narod</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Centre for Research in Women's Health, Women's College Hospital, Toronto, ON, Canada M5G 1N9;</nlm:aff><country>Canada</country><wicri:regionArea>Centre for Research in Women's Health, Women's College Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T." last="Lynch">Henry T. Lynch</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Preventive Medicine, Creighton University, Omaha, NE 68178;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Nebraska</region></placeName><wicri:cityArea>Department of Preventive Medicine, Creighton University, Omaha</wicri:cityArea></affiliation></author><author><name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">Cancer Research Campaign Department of Oncology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XZ, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research Campaign Department of Oncology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XZ</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eeles, Ros A" sort="Eeles, Ros A" uniqKey="Eeles R" first="Ros A." last="Eeles">Ros A. Eeles</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Cancer Genetics and Clinical Oncology, The Royal Marsden NHS Trust, Sutton, Surrey SM2 5PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genetics and Clinical Oncology, The Royal Marsden NHS Trust, Sutton, Surrey SM2 5PT</wicri:regionArea><wicri:noRegion>Surrey SM2 5PT</wicri:noRegion></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><affiliation><nlm:aff id="N0x9fa5f30.0x9b8b338">www.kconfab.org;</nlm:aff></affiliation><affiliation><nlm:aff id="N0x9fa5f30.0x9b8b338">www.kconfab.org;</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name></author><author><name sortKey="Lenoir, Gilbert" sort="Lenoir, Gilbert" uniqKey="Lenoir G" first="Gilbert" last="Lenoir">Gilbert Lenoir</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Weber, Barbara L" sort="Weber, Barbara L" uniqKey="Weber B" first="Barbara L." last="Weber">Barbara L. Weber</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Westmead Institute for Cancer Research, University of Sydney at Westmead, Millennium Institute, Westmead NSW 2145, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Westmead Institute for Cancer Research, University of Sydney at Westmead, Millennium Institute, Westmead NSW 2145</wicri:regionArea><wicri:noRegion>Westmead NSW 2145</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Westmead Institute for Cancer Research, University of Sydney at Westmead, Millennium Institute, Westmead NSW 2145, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Westmead Institute for Cancer Research, University of Sydney at Westmead, Millennium Institute, Westmead NSW 2145</wicri:regionArea><wicri:noRegion>Westmead NSW 2145</wicri:noRegion></affiliation></author><author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Cancer Genome Project, Sanger Centre, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Sanger Centre, Wellcome Trust Genome Campus, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">11792833</idno><idno type="pmc">117390</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117390</idno><idno type="RBID">PMC:117390</idno><idno type="doi">10.1073/pnas.012584499</idno><date when="2002">2002</date><idno type="wicri:Area/Pmc/Corpus">000A25</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A25</idno><idno type="wicri:Area/Pmc/Curation">000A02</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A02</idno><idno type="wicri:Area/Pmc/Checkpoint">002D46</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002D46</idno><idno type="wicri:Area/Ncbi/Merge">000043</idno><idno type="wicri:Area/Ncbi/Curation">000043</idno><idno type="wicri:Area/Ncbi/Checkpoint">000043</idno><idno type="wicri:doubleKey">0027-8424:2002:Thompson D:evaluation:of:linkage</idno><idno type="wicri:Area/Main/Merge">00C134</idno><idno type="wicri:Area/Main/Curation">00B345</idno><idno type="wicri:Area/Main/Exploration">00B345</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium</title><author><name sortKey="Thompson, Deborah" sort="Thompson, Deborah" uniqKey="Thompson D" first="Deborah" last="Thompson">Deborah Thompson</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Mangion, Jon" sort="Mangion, Jon" uniqKey="Mangion J" first="Jon" last="Mangion">Jon Mangion</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Oldenburg, Rogier A" sort="Oldenburg, Rogier A" uniqKey="Oldenburg R" first="Rogier A." last="Oldenburg">Rogier A. Oldenburg</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Seal, Sheila" sort="Seal, Sheila" uniqKey="Seal S" first="Sheila" last="Seal">Sheila Seal</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Barfoot, Rita" sort="Barfoot, Rita" uniqKey="Barfoot R" first="Rita" last="Barfoot">Rita Barfoot</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Kroeze Jansema, Karin" sort="Kroeze Jansema, Karin" uniqKey="Kroeze Jansema K" first="Karin" last="Kroeze-Jansema">Karin Kroeze-Jansema</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Teare, Dawn" sort="Teare, Dawn" uniqKey="Teare D" first="Dawn" last="Teare">Dawn Teare</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Renard, Helene" sort="Renard, Helene" uniqKey="Renard H" first="Hélène" last="Renard">Hélène Renard</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Mann, Graham" sort="Mann, Graham" uniqKey="Mann G" first="Graham" last="Mann">Graham Mann</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Westmead Institute for Cancer Research, University of Sydney at Westmead, Millennium Institute, Westmead NSW 2145, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Westmead Institute for Cancer Research, University of Sydney at Westmead, Millennium Institute, Westmead NSW 2145</wicri:regionArea><wicri:noRegion>Westmead NSW 2145</wicri:noRegion></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">Centre for Genetic Epidemiology, University of Melbourne, Melbourne 3002, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Genetic Epidemiology, University of Melbourne, Melbourne 3002</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Hematology–Oncology, University of Utah, Salt Lake City, UT 84132;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Department of Hematology–Oncology, University of Utah, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5;</nlm:aff><country>Canada</country><wicri:regionArea>Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Senie, Ruby" sort="Senie, Ruby" uniqKey="Senie R" first="Ruby" last="Senie">Ruby Senie</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Mailman School of Public Health, Columbia University, New York, NY 10032;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Mailman School of Public Health, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Fox Chase Cancer Center, Philadelphia, PA 19012;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Fox Chase Cancer Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="West, Dee" sort="West, Dee" uniqKey="West D" first="Dee" last="West">Dee West</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Northern California Cancer Center, Union City, CA 94587;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Northern California Cancer Center, Union City</wicri:cityArea></affiliation></author><author><name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Offit, Ken" sort="Offit, Ken" uniqKey="Offit K" first="Ken" last="Offit">Ken Offit</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Clinical Genetics Service, Department of Medicine, Memorial Sloan–Kettering Cancer Center, New York, NY 10021;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Clinical Genetics Service, Department of Medicine, Memorial Sloan–Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Peretz, Tamar" sort="Peretz, Tamar" uniqKey="Peretz T" first="Tamar" last="Peretz">Tamar Peretz</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Sharett Institute of Oncology, Hebrew University-Hadassah Medical Center, Jerusalem 91120, Israel;</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Sharett Institute of Oncology, Hebrew University-Hadassah Medical Center, Jerusalem 91120</wicri:regionArea><wicri:noRegion>Jerusalem 91120</wicri:noRegion></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Departmento de Genetica Humana, Centro Nacional Investigaciones Oncologicas, 28220 Madrid, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departmento de Genetica Humana, Centro Nacional Investigaciones Oncologicas, 28220 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J." last="Benitez">J. Benitez</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Departmento de Genetica Humana, Centro Nacional Investigaciones Oncologicas, 28220 Madrid, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departmento de Genetica Humana, Centro Nacional Investigaciones Oncologicas, 28220 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olàh">Edith Olàh</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Division of Molecular Biology, National Cancer Institute, H-1122, Budapest, Hungary;</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Division of Molecular Biology, National Cancer Institute, H-1122, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Bignon, Yves Jean" sort="Bignon, Yves Jean" uniqKey="Bignon Y" first="Yves-Jean" last="Bignon">Yves-Jean Bignon</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unité d'Oncogénétique and Unité INSERM CRI 9502 & EA 2145, Centre Jean-Perrin, 63011 Clermont-Ferrand, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité d'Oncogénétique and Unité INSERM CRI 9502 & EA 2145, Centre Jean-Perrin, 63011 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Ruiz, Pablo" sort="Ruiz, Pablo" uniqKey="Ruiz P" first="Pablo" last="Ruiz">Pablo Ruiz</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, 64460, Mexico;</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, 64460</wicri:regionArea><wicri:noRegion>64460</wicri:noRegion></affiliation></author><author><name sortKey="Badzioch, Michael D" sort="Badzioch, Michael D" uniqKey="Badzioch M" first="Michael D." last="Badzioch">Michael D. Badzioch</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Vasen, Hans F A" sort="Vasen, Hans F A" uniqKey="Vasen H" first="Hans F. A." last="Vasen">Hans F. A. Vasen</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Futreal, Andrew P" sort="Futreal, Andrew P" uniqKey="Futreal A" first="Andrew P." last="Futreal">Andrew P. Futreal</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Cancer Genome Project, Sanger Centre, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Sanger Centre, Wellcome Trust Genome Campus, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M." last="Phelan">Catherine M. Phelan</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Centre for Research in Women's Health, Women's College Hospital, Toronto, ON, Canada M5G 1N9;</nlm:aff><country>Canada</country><wicri:regionArea>Centre for Research in Women's Health, Women's College Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Narod, Steven A" sort="Narod, Steven A" uniqKey="Narod S" first="Steven A." last="Narod">Steven A. Narod</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Centre for Research in Women's Health, Women's College Hospital, Toronto, ON, Canada M5G 1N9;</nlm:aff><country>Canada</country><wicri:regionArea>Centre for Research in Women's Health, Women's College Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T." last="Lynch">Henry T. Lynch</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Preventive Medicine, Creighton University, Omaha, NE 68178;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Nebraska</region></placeName><wicri:cityArea>Department of Preventive Medicine, Creighton University, Omaha</wicri:cityArea></affiliation></author><author><name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">Cancer Research Campaign Department of Oncology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XZ, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research Campaign Department of Oncology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XZ</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eeles, Ros A" sort="Eeles, Ros A" uniqKey="Eeles R" first="Ros A." last="Eeles">Ros A. Eeles</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Cancer Genetics and Clinical Oncology, The Royal Marsden NHS Trust, Sutton, Surrey SM2 5PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genetics and Clinical Oncology, The Royal Marsden NHS Trust, Sutton, Surrey SM2 5PT</wicri:regionArea><wicri:noRegion>Surrey SM2 5PT</wicri:noRegion></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><affiliation><nlm:aff id="N0x9fa5f30.0x9b8b338">www.kconfab.org;</nlm:aff></affiliation><affiliation><nlm:aff id="N0x9fa5f30.0x9b8b338">www.kconfab.org;</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name></author><author><name sortKey="Lenoir, Gilbert" sort="Lenoir, Gilbert" uniqKey="Lenoir G" first="Gilbert" last="Lenoir">Gilbert Lenoir</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Weber, Barbara L" sort="Weber, Barbara L" uniqKey="Weber B" first="Barbara L." last="Weber">Barbara L. Weber</name><affiliation wicri:level="2"><nlm:aff id="N0x9fa5f30.0x9b8b338">Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="3"><nlm:aff id="N0x9fa5f30.0x9b8b338">Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics and Department of Pathology, Leiden University, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:aff id="N0x9fa5f30.0x9b8b338">CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research on Cancer, 69008 Lyon</wicri:regionArea><wicri:noRegion>69008 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Westmead Institute for Cancer Research, University of Sydney at Westmead, Millennium Institute, Westmead NSW 2145, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Westmead Institute for Cancer Research, University of Sydney at Westmead, Millennium Institute, Westmead NSW 2145</wicri:regionArea><wicri:noRegion>Westmead NSW 2145</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Westmead Institute for Cancer Research, University of Sydney at Westmead, Millennium Institute, Westmead NSW 2145, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Westmead Institute for Cancer Research, University of Sydney at Westmead, Millennium Institute, Westmead NSW 2145</wicri:regionArea><wicri:noRegion>Westmead NSW 2145</wicri:noRegion></affiliation></author><author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="N0x9fa5f30.0x9b8b338">Cancer Genome Project, Sanger Centre, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Sanger Centre, Wellcome Trust Genome Campus, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The known susceptibility genes for breast cancer, including BRCA1 and BRCA2, only account for a minority of the familial aggregation of the disease. A recent study of 77 multiple case breast cancer families from Scandinavia found evidence of linkage between the disease and polymorphic markers on chromosome 13q21. We have evaluated the contribution of this candidate “BRCA3” locus to breast cancer susceptibility in 128 high-risk breast cancer families of Western European ancestry with no identified BRCA1 or BRCA2 mutations. No evidence of linkage was found. The estimated proportion (α) of families linked to a susceptibility locus at D13S1308, the location estimated by Kainu <italic>et al.</italic> [(2000) <italic>Proc. Natl. Acad. Sci. USA</italic> 97, 9603–9608], was 0 (upper 95% confidence limit 0.13). Adjustment for possible bias due to selection of families on the basis of linkage evidence at BRCA2 did not materially alter this result (α = 0, upper 95% confidence limit 0.18). The proportion of linked families reported by Kainu <italic>et al.</italic> (0.65) is excluded with a high degree of confidence in our dataset [heterogeneity logarithm of odds (HLOD) at α = 0.65 was −11.0]. We conclude that, if a susceptibility gene does exist at this locus, it can only account for a small proportion of non-BRCA1/2 families with multiple cases of early-onset breast cancer.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Hongrie</li><li>Israël</li><li>Mexique</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li><li>Californie</li><li>Communauté de Madrid</li><li>Hollande-Méridionale</li><li>Hongrie centrale</li><li>Nebraska</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>Utah</li><li>Victoria (État)</li><li>Washington (État)</li><li>État de New York</li></region><settlement><li>Budapest</li><li>Cambridge</li><li>Clermont-Ferrand</li><li>Leyde</li><li>Lyon</li><li>Madrid</li><li>Melbourne</li></settlement><orgName><li>Université de Cambridge</li><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Thompson, Deborah" sort="Thompson, Deborah" uniqKey="Thompson D" first="Deborah" last="Thompson">Deborah Thompson</name></region><name sortKey="Barfoot, Rita" sort="Barfoot, Rita" uniqKey="Barfoot R" first="Rita" last="Barfoot">Rita Barfoot</name><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><name sortKey="Eeles, Ros A" sort="Eeles, Ros A" uniqKey="Eeles R" first="Ros A." last="Eeles">Ros A. Eeles</name><name sortKey="Eeles, Ros A" sort="Eeles, Ros A" uniqKey="Eeles R" first="Ros A." last="Eeles">Ros A. Eeles</name><name sortKey="Futreal, Andrew P" sort="Futreal, Andrew P" uniqKey="Futreal A" first="Andrew P." last="Futreal">Andrew P. Futreal</name><name sortKey="Mangion, Jon" sort="Mangion, Jon" uniqKey="Mangion J" first="Jon" last="Mangion">Jon Mangion</name><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><name sortKey="Seal, Sheila" sort="Seal, Sheila" uniqKey="Seal S" first="Sheila" last="Seal">Sheila Seal</name><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><name sortKey="Teare, Dawn" sort="Teare, Dawn" uniqKey="Teare D" first="Dawn" last="Teare">Dawn Teare</name><name sortKey="West, Dee" sort="West, Dee" uniqKey="West D" first="Dee" last="West">Dee West</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name></region><name sortKey="Badzioch, Michael D" sort="Badzioch, Michael D" uniqKey="Badzioch M" first="Michael D." last="Badzioch">Michael D. Badzioch</name><name sortKey="Bignon, Yves Jean" sort="Bignon, Yves Jean" uniqKey="Bignon Y" first="Yves-Jean" last="Bignon">Yves-Jean Bignon</name><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><name sortKey="Lenoir, Gilbert" sort="Lenoir, Gilbert" uniqKey="Lenoir G" first="Gilbert" last="Lenoir">Gilbert Lenoir</name><name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name><name sortKey="Renard, Helene" sort="Renard, Helene" uniqKey="Renard H" first="Hélène" last="Renard">Hélène Renard</name><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Oldenburg, Rogier A" sort="Oldenburg, Rogier A" uniqKey="Oldenburg R" first="Rogier A." last="Oldenburg">Rogier A. Oldenburg</name></region><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><name sortKey="Kroeze Jansema, Karin" sort="Kroeze Jansema, Karin" uniqKey="Kroeze Jansema K" first="Karin" last="Kroeze-Jansema">Karin Kroeze-Jansema</name><name sortKey="Vasen, Hans F A" sort="Vasen, Hans F A" uniqKey="Vasen H" first="Hans F. A." last="Vasen">Hans F. A. Vasen</name></country><country name="Australie"><noRegion><name sortKey="Mann, Graham" sort="Mann, Graham" uniqKey="Mann G" first="Graham" last="Mann">Graham Mann</name></noRegion><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></country><country name="États-Unis"><region name="Utah"><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name></region><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T." last="Lynch">Henry T. Lynch</name><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><name sortKey="Offit, Ken" sort="Offit, Ken" uniqKey="Offit K" first="Ken" last="Offit">Ken Offit</name><name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name><name sortKey="Senie, Ruby" sort="Senie, Ruby" uniqKey="Senie R" first="Ruby" last="Senie">Ruby Senie</name><name sortKey="Weber, Barbara L" sort="Weber, Barbara L" uniqKey="Weber B" first="Barbara L." last="Weber">Barbara L. Weber</name><name sortKey="West, Dee" sort="West, Dee" uniqKey="West D" first="Dee" last="West">Dee West</name></country><country name="Canada"><noRegion><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name></noRegion><name sortKey="Narod, Steven A" sort="Narod, Steven A" uniqKey="Narod S" first="Steven A." last="Narod">Steven A. Narod</name><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M." last="Phelan">Catherine M. Phelan</name></country><country name="Israël"><noRegion><name sortKey="Peretz, Tamar" sort="Peretz, Tamar" uniqKey="Peretz T" first="Tamar" last="Peretz">Tamar Peretz</name></noRegion></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name></region><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J." last="Benitez">J. Benitez</name></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olàh">Edith Olàh</name></region></country><country name="Mexique"><noRegion><name sortKey="Ruiz, Pablo" sort="Ruiz, Pablo" uniqKey="Ruiz P" first="Pablo" last="Ruiz">Pablo Ruiz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00B345 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00B345 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:117390
|texte= Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:11792833" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |